Researchers identify new type of nanoclusters for targeted imaging-guided combined cancer therapy

As a minimally invasive method for cancer therapy at precise locations, NIR-induced photothermal therapy (PTT) has drawn extensively attention. The therapeutic mechanism is the use of photothermal agents (PTAs) in the treatment of tumors,and its therapeutic effect happens only at the tumor site where both light-absorbent and localized laser radiation coexist.

The development of PTAs with NIR-II absorbance, ranging from 1000 nm to 1700 nm, can efficiently improve their penetrating ability and therapeutic effects because of their high penetration depth in the body. Howerever, several disadvantages are associated with these NIR-II responsive PTAs for their use in biomedical areas. Magnetic nanoparticles (MNPs), which boast strong absorption effect in NIR-II, can meet this demand. It has attracted much attention for biomedical applications with its noninvasive imaging function and magnetic-induced targeted ability.

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